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Latest Studies Imply That Cannabinoids are Protective Against Alcohol Induced Brain Damage

The administration of the synthetic cannabinoid agonist HU-211 decreases nerve cell death in an in vitro model of ethanol withdrawal, according to data published online in the journal of the Public Library of Science (PLoS ONE). An international team of researchers from France and Spain assessed the anti-excitotoxic effects of the synthetic cannabinoid HU-211 in culture. Researchers demonstrated that cannabinoid administration protected neurons from cell death in an experimental model of ethanol withdrawal. By contrast, the administration of a cannabinoid antagonist (rimonabant) during ethanol withdrawal greatly increased cell death. “[T]hese observations show, for the first time, that the stimulation of the endocannabinoid system could be protective against the hyper-excitability developed during alcohol withdrawal,” investigators concluded. “By contrast, the blockade of the endocannabinoid system seems to be counterproductive during alcohol withdrawal.” In humans, the abrupt cessation of alcohol in dependent subjects may be associated with tremor, delirium, brain damage, and death. Separate pre-clinical studies have previously documented that administration of the non-psychotropic organic cannabinoid cannabidiol (CBD) in animals is neuroprotective against cerebral infarction and ethanol-induced neurotoxicity (alcohol poisoning). In 2009 and 2010, a pair of studies conducted by investigators at the University of California at San Diego reported that the consumption of cannabis may offset certain alcohol-induced brain abnormalities, including the loss of white matter integrity and impaired memory, in human subjects with a history of both alcohol and marijuana use. Full text of the study appears online in PLoS ONE here.

Paul Armentano is co-author of the book Marijuana Is Safer: So Why Are We Driving People to Drink

Federal Cannabis Prohibition Turned 75-Years-Old on October 1

In a milestone that will no doubt go largely unnoticed by the mainstream media, today marks the 75th anniversary of the enactment of federal marijuana prohibition. On October 1, 1937, the US government criminally outlawed the possession and cultivation of cannabis — setting into motion a public policy that today results in some 850,000 arrests […] Read More..

Montana: Supreme Court Says Patients Possess No Fundamental Right To Cannabis

Members of the Montana Supreme Court ruled 6 to 1 on Tuesday that patients do not possess a fundamental right to access and consume cannabis for therapeutic purposes. The decision reverses a District Court ruling enjoining the state from enforcing various provisions of a 2011 state law that limits the public’s access to medical marijuana. […] Read More..

Study: Non-Psychotropic Cannabinoid “Proven To Be Safe” In Humans

The oral administration of the non-psychotropic cannabis plant constituent cannabidiol (CBD) is safe and well tolerated in humans, according to clinical trial data published online by the journal Current Pharmaceutical Design. Investigators at Kings College in London assessed the physiological and behavioral effects of CBD and THC versus placebo in 16 healthy volunteers in a […] Read More..

Michigan: Grand Rapids Voters Will Decide On $25 Fine-Only Offense For Pot Possession

Voters in Grand Rapids, Michigan will decide this November on a municipal measure to depenalize marijuana possession offenses to a non-criminal, fine-only offense. The City Commissioner’s office has approved the measure, Proposal 2, which seeks to allow local law enforcement the discretion to ticket first-time marijuana offenders with a civil citation, punishable by a $25 […] Read More..

Scientific Review: “There Is Now Clear Evidence That Cannabinoids Are Useful For The Treatment Of Various Medical Conditions”

For the second time in recent months, a scientific paper published in a peer-reviewed journal has thoroughly rebutted the present Schedule I status of cannabis under US federal law, which states that the plant and its organic constituents possess a “high potential for abuse,” and that they lack “accepted medical use” and “accepted safety … […] Read More..