Chelsea Green Publishing

The Blogging Community at Chelsea Green

Pot For Pain: The Verdict Is In

Editor’s note: This post is excerpted from this week’s forthcoming NORML weekly media advisory. To have NORML’s media advisories and legislative updates delivered straight to your in-box, sign up for ‘NORML News’ here.] Cannabis inhalation and the administration of cannabinoids are both associated with “significant analgesic effects” in the treatment of chronic non-cancer pain, according to a systemic review of randomized controlled trials to be published in the British Journal of Clinical Pharmacology. Investigators from the University of Toronto, Hospital for Sick Children, conducted a literature review regarding the efficacy of cannabinoids in the treatment of chronic pain, including neuropathic pain, fibromyalgia, rheumatoid arthritis, and mixed chronic pain. Eighteen randomized controlled trials published between 2003 and 2010 involving a total of 766 participants met inclusion criteria. Four of the trials assessed inhaled cannabis, while other studies assessed the analgesic properties of either plant-derived cannabinoids or synthetic cannabinoids. “Overall the quality of trials was excellent,” authors wrote. “Fifteen of the eighteen trials that met inclusion criteria demonstrated a significant analgesic effect of cannabinoid as compared to placebo, several reported significant improvements in sleep. There were no serious adverse effects.” Researchers noted that all four trials involving inhaled cannabis “found a positive effect with no serious adverse side effects.” They added: “Of special importance is the fact that two of the trials examining smoked cannabis demonstrated a significant analgesic effect in HIV neuropathy, a type of pain that has been notoriously resistant to other treatments normally used for neuropathic pain. In the trial examining cannabis based medicines in rheumatoid arthritis a significant reduction in disease activity was also noted, this is consistent with pre-clinical work demonstrating that cannabinoids are anti-inflammatory.” Investigators concluded, “[C]annabinoids are a modestly effective and safe treatment option for chronic non-cancer (predominantly neuropathic) pain. Given the prevalence of chronic pain, its impact on function and the paucity of effective therapeutic interventions, additional treatment options are urgently needed. More large-scale trials of longer duration reporting on pain and level of function are required.” NORML has additional information on the analgesic properties of cannabinoids in its handbook, Emerging Clinical Applications for Cannabis and Cannabinoids, here. Read the original post on the NORML blog.
marijuanaissafer Paul Armentano is the author of Marijuana Is Safer: So Why Are We Driving People To Drink?.


Federal Cannabis Prohibition Turned 75-Years-Old on October 1

In a milestone that will no doubt go largely unnoticed by the mainstream media, today marks the 75th anniversary of the enactment of federal marijuana prohibition. On October 1, 1937, the US government criminally outlawed the possession and cultivation of cannabis — setting into motion a public policy that today results in some 850,000 arrests […] Read More..

Montana: Supreme Court Says Patients Possess No Fundamental Right To Cannabis

Members of the Montana Supreme Court ruled 6 to 1 on Tuesday that patients do not possess a fundamental right to access and consume cannabis for therapeutic purposes. The decision reverses a District Court ruling enjoining the state from enforcing various provisions of a 2011 state law that limits the public’s access to medical marijuana. […] Read More..

Study: Non-Psychotropic Cannabinoid “Proven To Be Safe” In Humans

The oral administration of the non-psychotropic cannabis plant constituent cannabidiol (CBD) is safe and well tolerated in humans, according to clinical trial data published online by the journal Current Pharmaceutical Design. Investigators at Kings College in London assessed the physiological and behavioral effects of CBD and THC versus placebo in 16 healthy volunteers in a […] Read More..

Michigan: Grand Rapids Voters Will Decide On $25 Fine-Only Offense For Pot Possession

Voters in Grand Rapids, Michigan will decide this November on a municipal measure to depenalize marijuana possession offenses to a non-criminal, fine-only offense. The City Commissioner’s office has approved the measure, Proposal 2, which seeks to allow local law enforcement the discretion to ticket first-time marijuana offenders with a civil citation, punishable by a $25 […] Read More..

Scientific Review: “There Is Now Clear Evidence That Cannabinoids Are Useful For The Treatment Of Various Medical Conditions”

For the second time in recent months, a scientific paper published in a peer-reviewed journal has thoroughly rebutted the present Schedule I status of cannabis under US federal law, which states that the plant and its organic constituents possess a “high potential for abuse,” and that they lack “accepted medical use” and “accepted safety … […] Read More..